Michael Cordes

 

Biography:

Michael graduated with a B.S. in Chemistry from the University of Washington during which he interned both at Baylor with Dr. Solouki and at Washington with Dr. Matt Bush prior to joining the Gallagher Lab. He enjoys hiking, playing pickup soccer/basketball, and chess.

 

Current Area:

Michael works with tandem experimental Mass Spectrometry and Molecular Dynamics simulations for fundamental characterization of Electrospray Ionization and ion energetics in the gas phase.


 

Presentations:

Oral Presentations:

  1. “Comparing Native-protein Charging and Structures Associated with Different Modeling Techniques” Cordes, M.S.; Gallagher, E.S., Advancing Mass Spectrometry for Biophysics and Structural Biology Conference; Atlanta, Georgia; July 20-23, 2025.

  2. “MD Simulations of Native Protein Charging in Electrosprayed Droplets of Experimentally Relevant Composition” Cordes, M.S.; Gallagher, E.S., Lake Arrowhead Conference on Mass Spectrometry; Lake Arrowhead, California; January 17-19, 2025.

  3. "Comparing the Stability and Strength of Protein-Ligand Complexes in Positive- and Negative-Ion Mode Native-like Mass Spectrometry" Bannon, M.G.; Cordes, M.S.; Cupples, A.M.; Gallagher, E.S., 80th Southwest Regional Meeting of the American Chemical Society; Waco, Texas; October 20-23, 2024.

  4. “Modelling Protein Charging during Electrospray with Molecular Dynamics Protocol for Proton Exchange between Discrete Grotthuss Diffuse H3O+ and Proteins” Cordes, M.S.; Gallagher, E.S. 71st ASMS Conference on Mass Spectrometry and Allied Topics; Houston, Texas; June 4-8, 2023.

Poster Presentation:

  1. “Molecular Dynamic Simulations of Denatured proteins in Electrosprayed Droplets with H3O+ and Dynamic Protonation” Ryberg, S.S; Cordes, M.S.; Gallagher, E.S., Advancing Mass Spectrometry for Biophysics and Structural Biology Conference; Atlanta, Georgia; July 20-23, 2025.

  2. “Examining the Structure of Electrospray Native-Protein Ions upon Transition to the Gas-Phase” Cordes, M.S.; Gallagher, E.S., 73rd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, Maryland; June 1-5, 2025.

  3. "Molecular Dynamics Simulations of Native-Protein Charging in Electrosprayed Droplets with Experimentally Relevant Composition" Cordes, M.S.; Bannon, M.G., Gallagher, E.S., 80th Southwest Regional Meeting of the American Chemical Society; Waco, Texas; October 20-23, 2024.

  4. “Towards Comprehensive Molecular Dynamics Simulations of Native-Protein Charging in Electrosprayed Droplets” Cordes, M.S.; Gallagher E.S., 72nd ASMS Conference on Mass Spectrometry and Allied Topics; Anaheim, California; June 5-9, 2024.

  5. “Secondary Proton Transfer during Ion/Ion Reactions between Metal-Adducted Peptides and Fluoranthene” Gass, D.T.; Bannon, M.G.; Cordes, M.S.; Alberti, S.N.; Gallagher, E.S., 71st ASMS Conference on Mass Spectrometry and Allied Topics; Houston, Texas; June 4-8, 2023.

  6. “Determining the Gas-Phase Stability of Chloramphenicol Acetyltransferase (CAT) and the Effects of Ligand Binding” Edwards, A.N.; Blue, A.J.; Cordes, M.S.; Conforti, J.M.; Trakselis, M.A.; Gallagher, E.S., 71st ASMS Conference on Mass Spectrometry and Allied Topics; Houston, Texas; June 4-8, 2023.

  7. “Towards Understanding the Effect of Isoelectric Point on the Gas-Phase Stability of Proteins in Native MS” Edwards, A.N.; Cordes, M.S.; Gallagher, E.S., 71st ASMS Conference on Mass Spectrometry and Allied Topics; Houston, Texas; June 4-8, 2023.

  8. “Characterization of Carbohydrate Ionization Efficiencies in Electrospray as a Function of the Adducted Metal Ion” Cordes, M.S.; Gass, D.T.; Gallagher, E.S., 70th ASMS Conference on Mass Spectrometry and Allied Topics; Minneapolis, Minnesota; June 5-9, 2022.

  9. “Differences in the Stability of Metal-Carbohydrate Adducts Affect the Collisionally Dissociated Fragments Detected in Ion-Ion Reaction Spectra” Gass, D.T.; Cordes, M.S.; Alberti, S.; Gallagher, E.S. 70th ASMS Conference on Mass Spectrometry and Allied Topics; Minneapolis, Minnesota; June 5-9, 2022.

Publications:

  1. Edwards, A.N.; Bannon, M.G.; Cordes, M.S.; Gallagher, E.S. Investigating the effect of isoelectric points on the gas-phase stability of native-like proteins analyzed in positive- versus negative-ion mode by IMS-MS. ChemRxiv, 2025. DOI: 10.26434/chemrxiv-2025-vsfdx

  2. Cordes, M.S.; Gallagher, E.S. Molecular Dynamics Simulations of Native Protein Charging in Electrosprayed Droplets with Experimentally Relevant Compositions. J. Am. Chem. Soc. 2025, 147 (18), 15066-15076. DOI: 10.1021/jacs.4c17382

  3. Cordes, M.S.; Gallagher, E.S. Molecular Dynamics Simulations of Native Protein Charging via Proton Transfer during Electrospray Ionization with Grotthuss Diffuse H3O+. Anal. Chem. 2024, 96 (10), 4146-4153. DOI: 10.1021/acs.analchem.3c05089

  4. Gass, D.T.; Cordes, M.S.; Alberti, S.N.; Kim, H.J.; Gallagher, E.S. Evidence of H/D Exchange within Metal-Adducted Carbohydrates after Ion/Ion-Dissociation Reactions. J. Am. Chem. Soc. 2023, 145 (44), 23972-23985. DOI: 10.1021/jacs.3c05793

  5. Edwards, A.N.; Blue, A.J., Conforti, J.M., Cordes, M.S.; Trakselis, M.A., Gallagher, E.S. Gas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity. Anal. Bioanal. Chem. 2023, 415 (25), 6201-6212. DOI: 10.1007/s00216-023-04891-5

 

Organizations:

American Society of Mass Spectrometry (ASMS)

 

Awards:

2022-2025 Baylor University Travel Award

Email: Michael_Cordes@baylor.edu

LinkedIn: linkedin.com/in/michael-cordes-132b0b176

Contact Information: